Antiestrogens are designed to antagonize hormone induced proliferation and ERalpha target gene expression in mammary tumor cells. Commonly used drugs such as OH-Tamoxifen and ICI 182780 (Fulvestrant) block cell cycle progression in G0/G1. Inversely. the effect of cell cycle stage on ER regulated gene expression has not been tested directly. https://www.wholisticpet.shop/product-category/canine-grooming-bathing-products/