Polycythemia vera (PV) and essential thrombocythemia (ET) are two Philadelphia-negative myeloproliferative neoplasms (MPN) associated with an acquired mutation in the JAK2 tyrosine kinase gene. There is a rare incidence of progression to myelofibrosis and myeloid metaplasia in both disorders. which may or may not precede transformation to acute myeloid leukemia. but thrombosis is the ... https://www.shiinatactix.com/product-category/wire-craft-items/